Our latest work, ‘On-Chip Neural Induction Boosts Neural Stem Cell Commitment: Toward a Pipeline for iPSC-Based Therapies’, has been published in Advanced Science and featured in KTH press release.
The work has successfully demonstrated the first microfluidics platform to redirect iPSCs toward becoming neural stem cells. Here, a simple and cost-efficient microfluidic platform is developed to reprogram human fibroblasts into induced pluripotent stem cells (iPSCs) and further differentiate them into neural stem cells with boosted neural stem cell generation commitment. With further customization, the platform could be adapted for differentiation into other cell types, marking an important step towards making personalized cell-based therapies for Alzheimer’s and Parkinson’s disease more accessible.